Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions
نویسندگان
چکیده
منابع مشابه
Axonally Synthesized ATF4 Transmits a Neurodegenerative Signal across Brain Regions
In Alzheimer's disease (AD) brain, exposure of axons to Aβ causes pathogenic changes that spread retrogradely by unknown mechanisms, affecting the entire neuron. We found that locally applied Aβ1-42 initiates axonal synthesis of a defined set of proteins including the transcription factor ATF4. Inhibition of local translation and retrograde transport or knockdown of axonal Atf4 mRNA abolished A...
متن کاملExpanding Synthesized Signal Generation
Here are.two broadband, programmable, high-spectral-purity microwave signal sources, a 2-to-1 8-GHz synthesized signal generator and a 2-to-6.2-GHz synthesizer. Both are single, compact, 13-cm-high instruments. tr REQUENCY SYNTHESIZERS are signal sources l' that produce a selected output frequency by some type of arithmetic operation on a stable reference signal, which is usually derived from a...
متن کاملDepth of anesthesia estimation based on EEG signal using brain effective connectivity between frontal and temporal regions
Background: Ensuring adequate depth of anesthesia during surgery is essential for anesthesiologists to prevent the occurrence of unwanted alertness during surgery or failure to return to consciousness. Since the purpose of using anesthetics is to affect the central nervous system, brain signal processing such as electroencephalography (EEG) can be used to predict different levels of anesthesia....
متن کاملAxonally synthesized β-actin and GAP-43 proteins support distinct modes of axonal growth.
Increasing evidence points to the importance of local protein synthesis for axonal growth and responses to axotomy, yet there is little insight into the functions of individual locally synthesized proteins. We recently showed that expression of a reporter mRNA with the axonally localizing β-actin mRNA 3'UTR competes with endogenous β-actin and GAP-43 mRNAs for binding to ZBP1 and axonal localiz...
متن کاملa truncated PC - OFDM signal , and unmodulated PC / HC - MCM transmits a truncated PC - OFDM
SUMMARY A new type of modulation called continuous-phase parallel-combinatory high-compaction multicarrier modulation (CPPC/ HC-MCM) is proposed. CPPC/HC-MCM employs the technique of continuous-phase modulation (CPM) and avoids the formation of amplitude gaps between two successive signals to enhance the spectral efficiency of conventional PC/HC-MCM. Results of simulations show that CPPC/ HC-MC...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2014
ISSN: 0092-8674
DOI: 10.1016/j.cell.2014.07.001